The apelinergic system as an alternative to catecholamines in low-output septic shock.
Crit Care
; 22(1): 10, 2018 01 19.
Article
en En
| MEDLINE
| ID: mdl-29347994
ABSTRACT
Catecholamines, in concert with fluid resuscitation, have long been recommended in the management of septic shock. However, not all patients respond positively and controversy surrounding the efficacy-to-safety profile of catecholamines has emerged, trending toward decatecholaminization. Contextually, it is time to re-examine the "maintaining blood pressure" paradigm by identifying safer and life-saving alternatives. We put in perspective the emerging and growing knowledge on a promising alternative avenue the apelinergic system. This target exhibits invaluable pleiotropic properties, including inodilator activity, cardio-renal protection, and control of fluid homeostasis. Taken together, its effects are expected to be greatly beneficial for patients in septic shock.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Choque Séptico
/
Catecolaminas
/
Receptores de Apelina
Límite:
Humans
Idioma:
En
Revista:
Crit Care
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá