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Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists.
Kojima, Takuto; Mochizuki, Michiyo; Takai, Takafumi; Hoashi, Yasutaka; Morimoto, Sachie; Seto, Masaki; Nakamura, Minoru; Kobayashi, Katsumi; Sako, Yuu; Tanaka, Maiko; Kanzaki, Naoyuki; Kosugi, Yohei; Yano, Takahiko; Aso, Kazuyoshi.
Afiliación
  • Kojima T; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan. Electronic address: takuto.kojima@takeda.com.
  • Mochizuki M; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Takai T; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Hoashi Y; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Morimoto S; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Seto M; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Nakamura M; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Kobayashi K; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Sako Y; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Tanaka M; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Kanzaki N; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Kosugi Y; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Yano T; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Aso K; Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan.
Bioorg Med Chem ; 26(9): 2229-2250, 2018 05 15.
Article en En | MEDLINE | ID: mdl-29459145
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Bencimidazoles / Receptores de Hormona Liberadora de Corticotropina Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Bencimidazoles / Receptores de Hormona Liberadora de Corticotropina Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article