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Defining the sizes of airborne particles that mediate influenza transmission in ferrets.
Zhou, Jie; Wei, Jianjian; Choy, Ka-Tim; Sia, Sin Fun; Rowlands, Dewi K; Yu, Dan; Wu, Chung-Yi; Lindsley, William G; Cowling, Benjamin J; McDevitt, James; Peiris, Malik; Li, Yuguo; Yen, Hui-Ling.
Afiliación
  • Zhou J; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Wei J; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.
  • Choy KT; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Sia SF; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Rowlands DK; Laboratory Animal Services Centre, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Yu D; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Wu CY; Genomics Research Center, Academia Sinica, Taiwan, Republic of China.
  • Lindsley WG; Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505.
  • Cowling BJ; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • McDevitt J; Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.
  • Peiris M; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; malik@hku.hk hyen@hku.hk.
  • Li Y; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.
  • Yen HL; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; malik@hku.hk hyen@hku.hk.
Proc Natl Acad Sci U S A ; 115(10): E2386-E2392, 2018 03 06.
Article en En | MEDLINE | ID: mdl-29463703
ABSTRACT
Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aire / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Límite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aire / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Límite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: China