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Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse.
Summers, Matthew A; Vasiljevski, Emily R; Mikulec, Kathy; Peacock, Lauren; Little, David G; Schindeler, Aaron.
Afiliación
  • Summers MA; Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics & Child Heath, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia.
  • Vasiljevski ER; Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics & Child Heath, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia.
  • Mikulec K; Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia.
  • Peacock L; Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia.
  • Little DG; Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics & Child Heath, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia.
  • Schindeler A; Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics & Child Heath, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia. Electronic address: aaron.schindeler@sydney.edu.au.
Mol Genet Metab ; 123(4): 518-525, 2018 04.
Article en En | MEDLINE | ID: mdl-29477258
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzamidas / Neurofibromatosis 1 / Músculo Esquelético / Neurofibromina 1 / Difenilamina / Extremidades / Enfermedades Musculares Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Genet Metab Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzamidas / Neurofibromatosis 1 / Músculo Esquelético / Neurofibromina 1 / Difenilamina / Extremidades / Enfermedades Musculares Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Genet Metab Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Australia