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Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
Ebiloma, Godwin U; Ayuga, Teresa Díaz; Balogun, Emmanuel O; Gil, Lucía Abad; Donachie, Anne; Kaiser, Marcel; Herraiz, Tomás; Inaoka, Daniel K; Shiba, Tomoo; Harada, Shigeharu; Kita, Kiyoshi; de Koning, Harry P; Dardonville, Christophe.
Afiliación
  • Ebiloma GU; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Department of Biochemistry, Kogi State University, Anyigba, Nigeria.
  • Ayuga TD; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Balogun EO; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Japan; Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria.
  • Gil LA; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Donachie A; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Kaiser M; Swiss Tropical and Public Health Institute, Socinstrasse, 57, CH-4002 Basel, Switzerland.
  • Herraiz T; Instituto de Ciencia y Tecnología de Alimentos y Nutrición, ICTAN-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.
  • Inaoka DK; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Japan; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan.
  • Shiba T; Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
  • Harada S; Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
  • Kita K; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Japan; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan.
  • de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. Electronic address: Harry.De-Koning@glasgow.ac.uk.
  • Dardonville C; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain. Electronic address: dardonville@iqm.csic.es.
Eur J Med Chem ; 150: 385-402, 2018 Apr 25.
Article en En | MEDLINE | ID: mdl-29544150
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Parabenos / Proteínas de Plantas / Tripanocidas / Trypanosoma / Trypanosoma brucei brucei / Benzaldehídos / Trypanosoma congolense / Proteínas Mitocondriales Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Nigeria
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Parabenos / Proteínas de Plantas / Tripanocidas / Trypanosoma / Trypanosoma brucei brucei / Benzaldehídos / Trypanosoma congolense / Proteínas Mitocondriales Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Nigeria