Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain.
J Cereb Blood Flow Metab
; 39(10): 2096-2102, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-29569986
ABSTRACT
Glucose and oxygen metabolism are tightly coupled in the human brain, with the preponderance of the brain's glucose supply used to generate ATP via oxidative phosphorylation. A fraction of glucose is consumed outside of oxidative phosphorylation despite the presence of sufficient oxygen to do so. We refer to this process as aerobic glycolysis. A recent positron emission tomography study reported that aerobic glycolysis is uniform within gray matter. Here, we analyze the same data and demonstrate robust regional differences in aerobic glycolysis within gray matter, a finding consistent with previously published data.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Glucosa
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Glucólisis
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos