Association between serum uric acid level and multiple system atrophy: A meta-analysis.
Clin Neurol Neurosurg
; 169: 16-20, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29604506
ABSTRACT
OBJECTIVES:
Lower serum uric acid (UA) levels are considered to be related to the risk to develop many neurodegenerative disorders. However, the association between serum UA level and multiple system atrophy (MSA) remains controversial. The aim of this meta-analysis was to evaluate the relationship between serum UA level and MSA. PATIENTS ANDMETHODS:
PubMed, Web of Science, Embase, Cochrane Library and China National Knowledge Infrastructure (CNKI) were searched for eligible studies. Standardized mean difference (SMD) and 95% confidence intervals (95% CI) were calculated in a fixed-effects model or a random-effects model when appropriate. Subgroup analyses were carried out based on gender. A total of 6 eligible studies involving 547 MSA patients and 637 healthy individuals were identified.RESULTS:
Meta-analysis results revealed that individuals with MSA had lower sera levels of UA as compared with healthy controls (pooled SMD is -0.51, 95%CI -0.88 to -0.14; pâ¯=â¯0.006). The subgroup analysis to detect sex differences showed that the pooled SMD was -0.61 (95% CI -0.82 to -0.40; pâ¯<â¯0.0001) for males and -0.22 (95% CI -0.55 to 0.10; pâ¯=â¯0.18) for females compared with healthy controls.CONCLUSION:
Our meta-analysis revealed that lower serum level of UA is associated with an increased risk of MSA and the relationship is significant in men but not in women.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Úrico
/
Atrofia de Múltiples Sistemas
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Clin Neurol Neurosurg
Año:
2018
Tipo del documento:
Article