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Aminoglycoside exposure and renal function before lung transplantation in adult cystic fibrosis patients.
Novel-Catin, Etienne; Pelletier, Solenne; Reynaud, Quitterie; Nove-Josserand, Raphaele; Durupt, Stephane; Dubourg, Laurence; Durieu, Isabelle; Fouque, Denis.
Afiliación
  • Novel-Catin E; Département de Néphrologie, Centre Hospitalier Lyon SUD, Hospices Civils de Lyon, Pierre Bénite, France.
  • Pelletier S; Département de Néphrologie, Centre Hospitalier Lyon SUD, Hospices Civils de Lyon, Pierre Bénite, France.
  • Reynaud Q; Centre de Ressource et de Compétences Mucoviscidose, Hospices Civils de Lyon, Pierre Bénite, France.
  • Nove-Josserand R; EA 7425 HESPER, Université de Lyon, Lyon, France.
  • Durupt S; Centre de Ressource et de Compétences Mucoviscidose, Hospices Civils de Lyon, Pierre Bénite, France.
  • Dubourg L; Centre de Ressource et de Compétences Mucoviscidose, Hospices Civils de Lyon, Pierre Bénite, France.
  • Durieu I; Néphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
  • Fouque D; Centre de Ressource et de Compétences Mucoviscidose, Hospices Civils de Lyon, Pierre Bénite, France.
Nephrol Dial Transplant ; 34(1): 118-122, 2019 01 01.
Article en En | MEDLINE | ID: mdl-29684175
ABSTRACT

Background:

Patients with cystic fibrosis (CF) are at risk of kidney injury even before undergoing lung transplantation, because of prolonged exposure to aminoglycosides (AGs), chronic dehydration and complications of diabetes mellitus. The usual equations estimating the glomerular filtration rate (GFR), such as Cockcroft-Gault and Modification of Diet in Renal Disease, are not adapted to the CF population due to patients' low body weight and reduced muscle mass. The aim of this study was to precisely measure GFR in adult CF patients and to see whether repeated AG treatment would impair renal function before lung transplantation.

Methods:

Inulin or iohexol clearances were performed in 25 adult CF patients when they entered the lung transplant waiting list. No patient was treated with AGs at the time of GFR measurement. Body mass index (BMI), history of diabetes mellitus and blood pressure were recorded. Exposure to intravenous (IV) AGs within 5 years prior to the GFR measurement was obtained from the patient's medical files. Urine samples were collected to check for albuminuria and proteinuria.

Results:

The population was predominantly female (67%). The mean age was 32 years, the mean BMI was 19 kg/m2 and 28% had CF-related diabetes. Median exposure to IV AG within 5 years before GFR measurement was 155 days with a mean dosage of 7.7mg/kg/day. The mean measured GFR was 106 mL/min/1.73 m2 and the mean estimated GFR according to the Chronic Kidney Disease Epidemiology Collaboration formula was 124 mL/min/1.73 m2.

Conclusion:

Despite prolonged exposure to high-dose IV AG, no decline in GFR was observed in these patients.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Pulmón / Creatinina / Fibrosis Quística / Tasa de Filtración Glomerular / Aminoglicósidos / Riñón / Antibacterianos Límite: Adult / Female / Humans / Male Idioma: En Revista: Nephrol Dial Transplant Asunto de la revista: NEFROLOGIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Pulmón / Creatinina / Fibrosis Quística / Tasa de Filtración Glomerular / Aminoglicósidos / Riñón / Antibacterianos Límite: Adult / Female / Humans / Male Idioma: En Revista: Nephrol Dial Transplant Asunto de la revista: NEFROLOGIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Francia