cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
Science
; 241(4865): 585-9, 1988 Jul 29.
Article
en En
| MEDLINE
| ID: mdl-2969618
ABSTRACT
Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores Inmunológicos
/
Familia de Multigenes
/
Interleucina-1
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1988
Tipo del documento:
Article