Decarboxylation of Ang-(1-7) to Ala<sup>1</sup>-Ang-(1-7) leads to significant changes in pharmacodynamics.

Tetzner, Anja; Naughton, Maura; Gebolys, Kinga; Eichhorst, Jenny; Sala, Esther; Villacañas, Óscar; Walther, Thomas

Decarboxylation of Ang-(1-7) to Ala¹-Ang-(1-7) leads to significant changes in pharmacodynamics.

Tetzner, Anja; Naughton, Maura; Gebolys, Kinga; Eichhorst, Jenny; Sala, Esther; Villacañas, Óscar; Walther, Thomas.

Afiliación

Tetzner A; Dept. Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork (UCC), Cork, Ireland; Departments Obstetrics and Paediatric Surgery, University of Leipzig, Leipzig, Germany.
Naughton M; Dept. Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork (UCC), Cork, Ireland.
Gebolys K; Dept. Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork (UCC), Cork, Ireland.
Eichhorst J; Leibniz-Forschungsinstitut for Molekulare Pharmakologie (FMP), Berlin, Germany.
Sala E; Mind the Byte SL, Barcelona, Spain.
Villacañas Ó; Mind the Byte SL, Barcelona, Spain.
Walther T; Dept. Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork (UCC), Cork, Ireland; Departments Obstetrics and Paediatric Surgery, University of Leipzig, Leipzig, Germany; Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswal

Eur J Pharmacol ; 833: 116-123, 2018 Aug 15.

Article en En | MEDLINE | ID: mdl-29792841

Asunto(s)

Angiotensina I/metabolismo; Oligopéptidos/farmacología; Fragmentos de Péptidos/metabolismo; Proteínas Proto-Oncogénicas/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Animales; Células Cultivadas; AMP Cíclico/metabolismo; Descarboxilación; Células HEK293; Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Humanos; Células Mesangiales/efectos de los fármacos; Células Mesangiales/metabolismo; Ratones Noqueados; Proto-Oncogenes Mas; Proteínas Proto-Oncogénicas/genética; Receptores Acoplados a Proteínas G/genética

Palabras clave

Ala(1)-Angiotensin-(17); Dose-response curve; G-proteins; Mas receptor; MrgD receptor; Renin-angiotensin system

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Fragmentos de Péptidos / Angiotensina I / Proteínas Proto-Oncogénicas / Receptores Acoplados a Proteínas G Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Alemania

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