Probing seco-steroid inhibition of the hedgehog signaling pathway.
Mol Cell Biochem
; 450(1-2): 75-85, 2019 Jan.
Article
en En
| MEDLINE
| ID: mdl-29876765
ABSTRACT
Calcitriol, vitamin D3 (VD3), and structurally related VD3 analogues are inhibitors of Hh signaling in multiple contexts and are promising anti-cancer agents in Hh-dependent forms of cancer; however, the cellular mechanisms through which these compounds regulate Hh signal transmission are not clearly defined. Previous studies in this area have implicated both Smoothened, a key mediator of Hh signaling, and the vitamin D receptor (VDR) as potential mediators of Hh inhibition for this class of seco-steroids. We have performed a series of in vitro studies to more fully probe the cellular mechanisms that govern seco-steroid-mediated inhibition of Hh signaling. Our results support a role for both the Hh and VDR pathways in this process, as well as the possibility that other, as yet unidentified proteins, are also central to seco-steroid-mediated inhibition of Hh signaling.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Secoesteroides
/
Transducción de Señal
/
Receptores de Calcitriol
/
Proteínas Hedgehog
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biochem
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos