Mitochondria and aging: A role for the mitochondrial transition pore?
Aging Cell
; 17(4): e12793, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29888494
ABSTRACT
The cellular mechanisms responsible for aging are poorly understood. Aging is considered as a degenerative process induced by the accumulation of cellular lesions leading progressively to organ dysfunction and death. The free radical theory of aging has long been considered the most relevant to explain the mechanisms of aging. As the mitochondrion is an important source of reactive oxygen species (ROS), this organelle is regarded as a key intracellular player in this process and a large amount of data supports the role of mitochondrial ROS production during aging. Thus, mitochondrial ROS, oxidative damage, aging, and aging-dependent diseases are strongly connected. However, other features of mitochondrial physiology and dysfunction have been recently implicated in the development of the aging process. Here, we examine the potential role of the mitochondrial permeability transition pore (mPTP) in normal aging and in aging-associated diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Senescencia Celular
/
Proteínas de Transporte de Membrana Mitocondrial
/
Mitocondrias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Aging Cell
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia