Glycine <i>N</i>-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.

Hughey, Curtis C; Trefts, Elijah; Bracy, Deanna P; James, Freyja D; Donahue, E Patrick; Wasserman, David H

Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.

Hughey, Curtis C; Trefts, Elijah; Bracy, Deanna P; James, Freyja D; Donahue, E Patrick; Wasserman, David H.

Afiliación

Hughey CC; From the Department of Molecular Physiology and Biophysics and curtis.hughey@vanderbilt.edu.
Trefts E; From the Department of Molecular Physiology and Biophysics and.
Bracy DP; From the Department of Molecular Physiology and Biophysics and.
James FD; the Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee 37232.
Donahue EP; From the Department of Molecular Physiology and Biophysics and.
Wasserman DH; the Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee 37232.

J Biol Chem ; 293(30): 11944-11954, 2018 07 27.

Article en En | MEDLINE | ID: mdl-29891549

Asunto(s)

Carbono/metabolismo; Eliminación de Gen; Gluconeogénesis; Glicina N-Metiltransferasa/genética; Metionina/metabolismo; Animales; Ciclo del Ácido Cítrico; Metabolismo Energético; Hígado Graso/genética; Hígado Graso/metabolismo; Glucosa/metabolismo; Glicina N-Metiltransferasa/metabolismo; Hígado/metabolismo; Masculino; Análisis de Flujos Metabólicos; Ratones; Ratones Noqueados; S-Adenosilmetionina/metabolismo

Palabras clave

S-adenosylmethionine (SAM); energy metabolism; gluconeogenesis; intermediary metabolism; isotopic tracer; liver cancer; liver metabolism; liver steatosis; liver steatosis and cancer; metabolic flux analysis; one-carbon metabolism; polyamine; stable isotopes; transmethylation; transsulfuration

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carbono / Eliminación de Gen / Glicina N-Metiltransferasa / Gluconeogénesis / Metionina Límite: Animals Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google