Effects of 5% sodium chloride ophthalmic ointment on thickness and morphology of the normal canine cornea.
Vet Ophthalmol
; 22(3): 229-237, 2019 May.
Article
en En
| MEDLINE
| ID: mdl-29927055
ABSTRACT
OBJECTIVE:
To determine the effect of 5% sodium chloride ophthalmic ointment (5% NaCl) on thickness and morphology of the normal canine cornea using ultrasonic pachymetry (USP), in vivo confocal microscopy (IVCM), and Fourier-domain optical coherence tomography (FD-OCT).METHODS:
Five healthy laboratory Beagles received ophthalmic examinations including USP, IVCM, and FD-OCT prior to and at fixed intervals following treatment. The right and left eyes were treated with 5% NaCl and artificial tears ophthalmic ointment (AT), respectively, every 2 hours for 4 treatments/d (days 2-9), and then hourly for 7 treatments/d (day 10). Treatment groups were statistically compared using mixed-effects linear regression.RESULTS:
Treatment with 5% NaCl resulted in a 12 µm decrease in corneal thickness from baseline (P < .001), while there was no significant difference in corneal thickness between values obtained at baseline and following treatment with AT (P = .82). Epithelial cell density significantly increased from baseline (530 ± 52 cells/mm2 ) to 577 ± 43 and 567 ± 15 cells/mm2 with 5% NaCl and AT, respectively (P = .003 and .005, respectively). However, keratocyte cell density in the anterior and posterior stroma and endothelial cell density did not significantly differ following treatment with 5% NaCl or AT ointment (P > .05).CONCLUSIONS:
Short-term topical treatment with 5% NaCl decreased corneal thickness in normal dogs with no observable changes in corneal morphology or signs of ocular toxicity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Soluciones Oftálmicas
/
Córnea
/
Gotas Lubricantes para Ojos
/
Solución Salina
Límite:
Animals
Idioma:
En
Revista:
Vet Ophthalmol
Asunto de la revista:
MEDICINA VETERINARIA
/
OFTALMOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos