Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation.

Zhang, Hailong; Chen, Xi; Zong, Beibei; Yuan, Hongmin; Wang, Zhizeng; Wei, Yinxiang; Wang, Xuance; Liu, Guangchao; Zhang, Jun; Li, Shulian; Cheng, Guanchang; Wang, Yaohui; Ma, Yuanfang

Zhang, Hailong; Chen, Xi; Zong, Beibei; Yuan, Hongmin; Wang, Zhizeng; Wei, Yinxiang; Wang, Xuance; Liu, Guangchao; Zhang, Jun; Li, Shulian; Cheng, Guanchang; Wang, Yaohui; Ma, Yuanfang.

Afiliación

Zhang H; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Chen X; Department of General Pathology, Huaihe Hospital, Henan University, Kaifeng, China.
Zong B; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Yuan H; Department of Thyroid Breast Surgery, Huaihe Hospital, Henan University, Kaifeng, China.
Wang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Wei Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Wang X; Centre for Translational Medicine, Huaihe Hospital, Henan University, Kaifeng, China.
Liu G; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Zhang J; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Li S; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Cheng G; Department of Cardiac Surgery, Huaihe Hospital, Henan University, Kaifeng, China.
Wang Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Ma Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.

J Cell Mol Med ; 22(9): 4437-4448, 2018 09.

Article en En | MEDLINE | ID: mdl-29993180

Asunto(s)

Antioxidantes/farmacología; Cardiotónicos/farmacología; Diabetes Mellitus Experimental/tratamiento farmacológico; Cardiomiopatías Diabéticas/tratamiento farmacológico; Inflamasomas/efectos de los fármacos; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Animales; Antioxidantes/aislamiento & purificación; Glucemia/efectos de los fármacos; Glucemia/metabolismo; Cardiotónicos/aislamiento & purificación; Proteínas Portadoras/genética; Proteínas Portadoras/metabolismo; Línea Celular; Citocromos c/genética; Citocromos c/metabolismo; Diabetes Mellitus Experimental/inducido químicamente; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/patología; Cardiomiopatías Diabéticas/inducido químicamente; Cardiomiopatías Diabéticas/genética; Cardiomiopatías Diabéticas/patología; Regulación de la Expresión Génica; Gynostemma/química; Inflamasomas/metabolismo; Interleucina-18/genética; Interleucina-18/metabolismo; Interleucina-1beta/genética; Interleucina-1beta/metabolismo; Masculino; Miocitos Cardíacos/citología; Miocitos Cardíacos/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/agonistas; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Estrés Oxidativo; Extractos Vegetales/aislamiento & purificación; Extractos Vegetales/farmacología; Ratas; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/antagonistas & inhibidores; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal; Estreptozocina

Palabras clave

NLRP3 inflammasome; ROS; cytochrome c; diabetic cardiomyopathy; gypenosides; high glucose

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cardiotónicos / Diabetes Mellitus Experimental / Cardiomiopatías Diabéticas / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Antioxidantes Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: China

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