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Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis.
Li, Xiaokang; Huang, Yahui; Cheng, Junfei; Zhang, Lingling; Mao, Fei; Zhu, Jin; Sheng, Chunquan; Li, Jian.
Afiliación
  • Li X; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
  • Huang Y; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
  • Cheng J; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
  • Zhang L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
  • Mao F; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
  • Zhu J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
  • Sheng C; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China. Electronic address: shengcq@smmu.edu.cn.
  • Li J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China. Electronic address: jianli@ecust.edu.cn.
Bioorg Med Chem ; 26(15): 4375-4381, 2018 08 15.
Article en En | MEDLINE | ID: mdl-30078608
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Proteínas Proto-Oncogénicas c-kit / Receptor alfa de Factor de Crecimiento Derivado de Plaquetas / Inhibidores de Proteínas Quinasas / Proliferación Celular / Quinasa Syk Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Proteínas Proto-Oncogénicas c-kit / Receptor alfa de Factor de Crecimiento Derivado de Plaquetas / Inhibidores de Proteínas Quinasas / Proliferación Celular / Quinasa Syk Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article