Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-&#954;B Signaling after Nuclear DNA Damage.

Dunphy, Gillian; Flannery, Sinéad M; Almine, Jessica F; Connolly, Dympna J; Paulus, Christina; Jønsson, Kasper L; Jakobsen, Martin R; Nevels, Michael M; Bowie, Andrew G; Unterholzner, Leonie

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.

Dunphy, Gillian; Flannery, Sinéad M; Almine, Jessica F; Connolly, Dympna J; Paulus, Christina; Jønsson, Kasper L; Jakobsen, Martin R; Nevels, Michael M; Bowie, Andrew G; Unterholzner, Leonie.

Afiliación

Dunphy G; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK.
Flannery SM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Almine JF; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK.
Connolly DJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Paulus C; Biomedical Sciences Research Complex, University of St Andrews, St Andrews KY16 9ST, UK.
Jønsson KL; Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, 8000 Aarhus C, Denmark.
Jakobsen MR; Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, 8000 Aarhus C, Denmark.
Nevels MM; Biomedical Sciences Research Complex, University of St Andrews, St Andrews KY16 9ST, UK.
Bowie AG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Unterholzner L; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address: l.unterholzner@lancaster.ac.uk.

Mol Cell ; 71(5): 745-760.e5, 2018 09 06.

Article en En | MEDLINE | ID: mdl-30193098

Asunto(s)

Proteínas de la Ataxia Telangiectasia Mutada/genética; Núcleo Celular/genética; Daño del ADN/genética; Proteínas de la Membrana/genética; FN-kappa B/genética; Proteínas Nucleares/genética; Fosfoproteínas/genética; Transducción de Señal/genética; Línea Celular; Citosol/metabolismo; ADN/genética; Células HEK293; Humanos; Inmunidad Innata/genética; Queratinocitos/fisiología; Poli(ADP-Ribosa) Polimerasa-1/genética; Proteína p53 Supresora de Tumor/genética; Ubiquitina/genética; Ubiquitina-Proteína Ligasas/genética

Palabras clave

DNA damage; IFI16; STING; TRAF6; etoposide; innate immunity; interferon; p53; ubiquitin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfoproteínas / Daño del ADN / Proteínas Nucleares / Transducción de Señal / Núcleo Celular / FN-kappa B / Proteínas de la Ataxia Telangiectasia Mutada / Proteínas de la Membrana Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido

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