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Design, synthesis, and evaluation of chalcone analogues incorporate α,ß-Unsaturated ketone functionality as anti-lung cancer agents via evoking ROS to induce pyroptosis.
Zhu, Min; Wang, Jiabing; Xie, Jingwen; Chen, Liping; Wei, Xiaoyan; Jiang, Xing; Bao, Miao; Qiu, Yanyi; Chen, Qian; Li, Wulan; Jiang, Chengxi; Zhou, Xiaoou; Jiang, Liping; Qiu, Peihong; Wu, Jianzhang.
Afiliación
  • Zhu M; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Wang J; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, Zhejiang, 318000, China.
  • Xie J; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Chen L; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Wei X; Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Jiang X; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Bao M; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Qiu Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Chen Q; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Li W; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; College of Information Science and Computer Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Jiang C; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Zhou X; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
  • Jiang L; Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
  • Qiu P; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Electronic address: wjzwzmc@126.com.
  • Wu J; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Electronic address: wjzwzmu@163.com.
Eur J Med Chem ; 157: 1395-1405, 2018 Sep 05.
Article en En | MEDLINE | ID: mdl-30196062
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Chalcona / Especies Reactivas de Oxígeno / Piroptosis / Cetonas / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Chalcona / Especies Reactivas de Oxígeno / Piroptosis / Cetonas / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: China