Overproduction of protein p53 contributes to simian virus 40-mediated transformation.
Mol Cell Biol
; 6(10): 3531-6, 1986 Oct.
Article
en En
| MEDLINE
| ID: mdl-3025598
ABSTRACT
The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Transformación Celular Viral
/
Virus 40 de los Simios
/
Genes
/
Genes Virales
/
Proteínas de Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
1986
Tipo del documento:
Article