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Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia.
Bariana, Tadbir K; Labarque, Veerle; Heremans, Jessica; Thys, Chantal; De Reys, Mara; Greene, Daniel; Jenkins, Benjamin; Grassi, Luigi; Seyres, Denis; Burden, Frances; Whitehorn, Deborah; Shamardina, Olga; Papadia, Sofia; Gomez, Keith; BioResource, Nihr; Van Geet, Chris; Koulman, Albert; Ouwehand, Willem H; Ghevaert, Cedric; Frontini, Mattia; Turro, Ernest; Freson, Kathleen.
Afiliación
  • Bariana TK; Department of Haematology, University College London, UK.
  • Labarque V; The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London NHS Foundation Trust, UK.
  • Heremans J; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
  • Thys C; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
  • De Reys M; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
  • Greene D; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
  • Jenkins B; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
  • Grassi L; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
  • Seyres D; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
  • Burden F; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
  • Whitehorn D; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
  • Shamardina O; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.
  • Papadia S; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK.
  • Gomez K; NIHR Biomedical Research Centre Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge Biomedical Campus, UK.
  • BioResource N; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
  • Van Geet C; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
  • Koulman A; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.
  • Ouwehand WH; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK.
  • Ghevaert C; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
  • Frontini M; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
  • Turro E; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.
  • Freson K; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK.
Haematologica ; 104(5): 1036-1045, 2019 05.
Article en En | MEDLINE | ID: mdl-30467204
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esfingolípidos / Trombocitopenia / Plaquetas / Megacariocitos / Oxidorreductasas de Alcohol / Células Madre Pluripotentes Inducidas Tipo de estudio: Prognostic_studies Límite: Animals / Child / Female / Humans / Male Idioma: En Revista: Haematologica Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esfingolípidos / Trombocitopenia / Plaquetas / Megacariocitos / Oxidorreductasas de Alcohol / Células Madre Pluripotentes Inducidas Tipo de estudio: Prognostic_studies Límite: Animals / Child / Female / Humans / Male Idioma: En Revista: Haematologica Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido