Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription.

Ding, Yuhua; Xu, Huihui; Li, Luyang; Yuan, Yibiao; Xu, Yong

Ding, Yuhua; Xu, Huihui; Li, Luyang; Yuan, Yibiao; Xu, Yong.

Afiliación

Ding Y; Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xu H; Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China.
Li L; Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China.
Yuan Y; The Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, China. Electronic address: yuanyb@njmu.edu.cn.
Xu Y; Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China; Institute of Biomedical Research, Liaocheng University, Liaocheng, China. Electr

Biochem Biophys Res Commun ; 509(3): 633-640, 2019 02 12.

Article en En | MEDLINE | ID: mdl-30553442

Asunto(s)

Retinopatía Diabética/metabolismo; Transición Epitelial-Mesenquimal; Hiperglucemia/metabolismo; Proteína-Lisina 6-Oxidasa/genética; Epitelio Pigmentado de la Retina/metabolismo; Transactivadores/metabolismo; Activación Transcripcional; Línea Celular; Retinopatía Diabética/complicaciones; Retinopatía Diabética/genética; Retinopatía Diabética/patología; Glucosa/metabolismo; Humanos; Hiperglucemia/complicaciones; Hiperglucemia/genética; Hiperglucemia/patología; Proteína-Lisina 6-Oxidasa/metabolismo; Epitelio Pigmentado de la Retina/patología

Palabras clave

Diabetic retinopathy; EMT; Retinal epithelial cell; Transcriptional regulation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Activación Transcripcional / Transactivadores / Retinopatía Diabética / Epitelio Pigmentado de la Retina / Transición Epitelial-Mesenquimal / Hiperglucemia / Proteína-Lisina 6-Oxidasa Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article País de afiliación: China

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