Visualization and Cytotoxicity of Fluorescence-Labeled Dimeric Magnetite-Gold Nanoparticles Conjugated with Prostate-Specific Membrane Antigen in Mouse Macrophages.
Bull Exp Biol Med
; 166(3): 386-389, 2019 Jan.
Article
en En
| MEDLINE
| ID: mdl-30627898
ABSTRACT
We demonstrated the possibility of penetration of magnetite-gold nanoparticles conjugated with prostate-specific membrane antigen into mouse macrophages. It was found that after 3-h incubation with nanoparticles in a concentration of 15 mg/liter at 37oC, they were seen in only 13% macrophages. In about 90% cells, the nanoparticles were detected within the cytoplasm. Under these conditions, membrane damage was revealed in 25% cells. These results should be taken into account in further development and application of nanomaterials for diagnostic and therapeutic purposes in oncology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Muerte Celular
/
Macrófagos Peritoneales
/
Medios de Contraste
/
Glutamato Carboxipeptidasa II
/
Nanopartículas de Magnetita
/
Antígenos de Superficie
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia