Acrepyrone A, a new <i>Î³</i>-pyrone derivative from an endophytic fungus, <i>Acremonium citrinum</i> SS-g13.

Peng, Xiao-Ping; Li, Gang; Ji, Li-Xia; Li, Ying-Xia; Lou, Hong-Xiang

Acrepyrone A, a new Î³-pyrone derivative from an endophytic fungus, Acremonium citrinum SS-g13.

Peng, Xiao-Ping; Li, Gang; Ji, Li-Xia; Li, Ying-Xia; Lou, Hong-Xiang.

Afiliación

Peng XP; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.
Li G; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.
Ji LX; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.
Li YX; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.
Lou HX; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.

Nat Prod Res ; 34(8): 1091-1096, 2020 Apr.

Article en En | MEDLINE | ID: mdl-30663360

ABSTRACT

ABSTRACT

A new Î³-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determined by analysing MS, NMR, and ECD data. Compound 1 was evaluated for its cytotoxic effect, antibacterial activity and quorum sensing inhibitory potential.

Asunto(s)

Acremonium/química; Plantas Medicinales/microbiología; Pironas/aislamiento & purificación; Antibacterianos/química; Antibacterianos/aislamiento & purificación; Antibacterianos/farmacología; Citotoxinas/química; Citotoxinas/aislamiento & purificación; Citotoxinas/farmacología; Endófitos/química; Humanos; Estructura Molecular; Raíces de Plantas/efectos de los fármacos; Pironas/química; Percepción de Quorum/efectos de los fármacos

Palabras clave

Endophytes; bioactivities; natural products; Î³-pyrone derivative

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plantas Medicinales / Pironas / Acremonium Límite: Humans Idioma: En Revista: Nat Prod Res Año: 2020 Tipo del documento: Article

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