Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.

Wang, Huabo; Lu, Jie; Kulkarni, Sucheta; Zhang, Weiqi; Gorka, Joanna E; Mandel, Jordan A; Goetzman, Eric S; Prochownik, Edward V

Wang, Huabo; Lu, Jie; Kulkarni, Sucheta; Zhang, Weiqi; Gorka, Joanna E; Mandel, Jordan A; Goetzman, Eric S; Prochownik, Edward V.

Afiliación

Wang H; From the Section of Hematology/Oncology and.
Lu J; From the Section of Hematology/Oncology and.
Kulkarni S; From the Section of Hematology/Oncology and.
Zhang W; From the Section of Hematology/Oncology and.
Gorka JE; From the Section of Hematology/Oncology and.
Mandel JA; From the Section of Hematology/Oncology and.
Goetzman ES; Division of Medical Genetics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224.
Prochownik EV; From the Section of Hematology/Oncology and procev@chp.edu.

J Biol Chem ; 294(14): 5466-5486, 2019 04 05.

Article en En | MEDLINE | ID: mdl-30755479

Asunto(s)

Ciclo del Ácido Cítrico; Fibroblastos/metabolismo; Potencial de la Membrana Mitocondrial; Consumo de Oxígeno; Complejo Piruvato Deshidrogenasa/genética; Animales; Línea Celular Tumoral; Proliferación Celular; Fibroblastos/patología; Humanos; Complejo Piruvato Deshidrogenasa/metabolismo; Ratas; Ratas Mutantes

Palabras clave

Myc (c-Myc); Warburg effect; fatty acid oxidation; glutaminolysis; pyruvate carboxylase (PC); reverse carboxylation; tricarboxylic acid cycle (TCA cycle) (Krebs cycle)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Complejo Piruvato Deshidrogenasa / Ciclo del Ácido Cítrico / Potencial de la Membrana Mitocondrial / Fibroblastos Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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