Do sex differences in chronic disease underpin the sex-frailty paradox?
Mech Ageing Dev
; 179: 44-50, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30825457
ABSTRACT
The 'male-female health-survival paradox' is a well-described clinical phenomenon. More recently, it has been conceptualized as a 'sex-frailty paradox' females may be considered to be more frail (because they have poorer health status) but also less frail (because they are less vulnerable to death) than males of the same age. Here, we review potential biological, behavioral and social mechanisms underpinning sex differences in morbidity, mortality and frailty before considering the question at the center of the sex paradox - why is it that females are able to tolerate poor health better than males? We explore, in detail, a frequently cited explanation for the sex paradox that centers on sex differences in chronic disease and conclude by presenting a new approach to this old hypothesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores Sexuales
/
Enfermedad Crónica
/
Anciano Frágil
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
/
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Mech Ageing Dev
Año:
2019
Tipo del documento:
Article