Proximal motor neuropathy, dermato-endocrine syndrome, and IgG kappa paraproteinemia.
Arch Neurol
; 43(8): 845-8, 1986 Aug.
Article
en En
| MEDLINE
| ID: mdl-3089203
ABSTRACT
The association of monoclonal paraproteinemia, neuropathy, and dermato-endocrine disturbances is well recognized in Japan, and it also occurs in white patients. Neuropathy in such patients is classically distal and sensorimotor, and the paraprotein almost always contains lambda light chains. A 58-year-old white man presented with severe progressive proximal motor neuropathy, dermato-endocrine changes, and an IgG kappa paraprotein. Over a 2 1/2-year period, treatment with melphalan and prednisolone produced improvement in the neuropathy and resolution of dermato-endocrine features with a corresponding decline in the serum paraprotein concentration. Subsequent reappearance of the paraprotein, despite treatment, was associated with clinical relapse.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Paraproteinemias
/
Enfermedades de la Piel
/
Cadenas kappa de Inmunoglobulina
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Enfermedades del Sistema Endocrino
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Neuronas Motoras
/
Enfermedades Neuromusculares
Límite:
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Arch Neurol
Año:
1986
Tipo del documento:
Article