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Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
Zhang, Yan; Wu, Xishan; Xue, Xiaoqian; Li, Chenchang; Wang, Junjian; Wang, Rui; Zhang, Cheng; Wang, Chao; Shi, Yudan; Zou, Lingjiao; Li, Qiu; Huang, Zenghong; Hao, Xiaojuan; Loomes, Kerry; Wu, Donghai; Chen, Hong-Wu; Xu, Jinxin; Xu, Yong.
Afiliación
  • Zhang Y; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Wu X; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Xue X; Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL) , Guangzhou 510530 , China.
  • Li C; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Wang J; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Wang R; Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL) , Guangzhou 510530 , China.
  • Zhang C; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Wang C; School of Life Science , Huizhou University , Huizhou 516007 , China.
  • Shi Y; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Zou L; School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , China.
  • Li Q; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Huang Z; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Hao X; School of Pharmaceutical Sciences , Jilin University , No.1266 Fujin Road , Chaoyang District, Changchun , Jilin 130021 , China.
  • Loomes K; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Wu D; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Chen HW; Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL) , Guangzhou 510530 , China.
  • Xu J; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University, Guangzhou 510530 , China.
  • Xu Y; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
J Med Chem ; 62(9): 4716-4730, 2019 05 09.
Article en En | MEDLINE | ID: mdl-30964293
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Miembro 3 del Grupo F de la Subfamilia 1 de Receptores Nucleares / Neoplasias de la Próstata Resistentes a la Castración / Acetanilidas / Antineoplásicos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Miembro 3 del Grupo F de la Subfamilia 1 de Receptores Nucleares / Neoplasias de la Próstata Resistentes a la Castración / Acetanilidas / Antineoplásicos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China