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Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway.
Jo, Myungjin; Lee, Shinrye; Kim, Kiyoung; Lee, Seongsoo; Kim, Sang Ryong; Kim, Hyung-Jun.
Afiliación
  • Jo M; Korea Brain Research Institute, Department of Neural Development and Disease, 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
  • Lee S; Korea Brain Research Institute, Department of Neural Development and Disease, 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
  • Kim K; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, 31151, South Korea; Department of Medical Biotechnology, Soonchunhyang University, Asan, 31538, South Korea.
  • Lee S; Gwangju Center, Korea Basic Science Institute (KBSI), Gwangju, 61186, South Korea.
  • Kim SR; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Institute of Life Science & Biotechnology, Kyungpook National University, Daegu, 41566, South Korea; Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41944, South Korea.
  • Kim HJ; Korea Brain Research Institute, Department of Neural Development and Disease, 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea. Electronic address: kijang1@kbri.re.kr.
Biochem Biophys Res Commun ; 513(4): 925-932, 2019 06 11.
Article en En | MEDLINE | ID: mdl-31005259
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / MAP Quinasa Quinasa 5 / Proteínas de Unión al ADN / Redes y Vías Metabólicas / Lisosomas / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / MAP Quinasa Quinasa 5 / Proteínas de Unión al ADN / Redes y Vías Metabólicas / Lisosomas / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article