The Microbiome and Food Allergy.
Annu Rev Immunol
; 37: 377-403, 2019 04 26.
Article
en En
| MEDLINE
| ID: mdl-31026410
ABSTRACT
The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of food proteins yearly. It must distinguish these harmless antigens from potential pathogens and mount the appropriate host immune response. Local and systemic hyporesponsiveness to dietary antigens, classically referred to as oral tolerance, comprises a distinct complement of adaptive cellular and humoral immune responses. It is increasingly evident that a functional epithelial barrier engaged in intimate interplay with innate immune cells and the resident microbiota is critical to establishing and maintaining oral tolerance. Moreover, innate immune cells serve as a bridge between the microbiota, epithelium, and the adaptive immune system, parlaying tonic microbial stimulation into signals critical for mucosal homeostasis. Dysregulation of gut homeostasis and the subsequent disruption of tolerance therefore have clinically significant consequences for the development of food allergy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Disbiosis
/
Microbioma Gastrointestinal
/
Hipersensibilidad a los Alimentos
/
Mucosa Intestinal
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2019
Tipo del documento:
Article