Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.

Pearson, Stephanie; Loft, Anne; Rajbhandari, Prashant; Simcox, Judith; Lee, Sanghoon; Tontonoz, Peter; Mandrup, Susanne; Villanueva, Claudio J

Pearson, Stephanie; Loft, Anne; Rajbhandari, Prashant; Simcox, Judith; Lee, Sanghoon; Tontonoz, Peter; Mandrup, Susanne; Villanueva, Claudio J.

Afiliación

Pearson S; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Loft A; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Rajbhandari P; Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA.
Simcox J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Lee S; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Tontonoz P; Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA.
Mandrup S; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Villanueva CJ; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.

Genes Dev ; 33(13-14): 747-762, 2019 07 01.

Article en En | MEDLINE | ID: mdl-31123067

Asunto(s)

Adipocitos Beige/metabolismo; Proteínas Co-Represoras/genética; Proteínas Co-Represoras/metabolismo; Glucosa/metabolismo; Animales; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo; Células Cultivadas; Dieta Alta en Grasa; Metabolismo Energético/genética; Eliminación de Gen; Regulación de la Expresión Génica/genética; Estudio de Asociación del Genoma Completo; Resistencia a la Insulina/genética; Masculino; Ratones; Ratones Endogámicos C57BL; Mitocondrias/genética; Mitocondrias/metabolismo; Termogénesis/genética

Palabras clave

TLE3; adipocytes; beige adipocytes; development; diabetes; metabolism; thermogenesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Co-Represoras / Adipocitos Beige / Glucosa Límite: Animals Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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