Gamma-secretase complex-dependent intramembrane proteolysis of CD147 regulates the Notch1 signaling pathway in hepatocellular carcinoma.

Yong, Yu-Le; Zhang, Ren-Yu; Liu, Ze-Kun; Wei, Ding; Shang, Yu-Kui; Wu, Jiao; Zhang, Zhi-Yun; Li, Can; Chen, Zhi-Nan; Bian, Huijie

Yong, Yu-Le; Zhang, Ren-Yu; Liu, Ze-Kun; Wei, Ding; Shang, Yu-Kui; Wu, Jiao; Zhang, Zhi-Yun; Li, Can; Chen, Zhi-Nan; Bian, Huijie.

Afiliación

Yong YL; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Zhang RY; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Liu ZK; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Wei D; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Shang YK; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Wu J; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Zhang ZY; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Li C; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Chen ZN; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.
Bian H; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, PR China.

J Pathol ; 249(2): 255-267, 2019 10.

Article en En | MEDLINE | ID: mdl-31215640

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/metabolismo; Basigina/metabolismo; Carcinoma Hepatocelular/enzimología; Proliferación Celular; Neoplasias Hepáticas/enzimología; Receptor Notch1/metabolismo; Transporte Activo de Núcleo Celular; Animales; Antineoplásicos Inmunológicos/farmacología; Basigina/antagonistas & inhibidores; Basigina/genética; Sitios de Unión; Carcinoma Hepatocelular/tratamiento farmacológico; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Femenino; Regulación Neoplásica de la Expresión Génica; Humanos; Neoplasias Hepáticas/tratamiento farmacológico; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Masculino; Ratones Endogámicos BALB C; Ratones Desnudos; Regiones Promotoras Genéticas; Proteolisis; Receptor Notch1/genética; Transducción de Señal; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

CD147; Notch1; Sox9; cyclin D1; hepatocellular carcinoma; Î³-secretase complex

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Proliferación Celular / Basigina / Receptor Notch1 / Secretasas de la Proteína Precursora del Amiloide / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Pathol Año: 2019 Tipo del documento: Article

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