In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products.

Komatsu, Takashi E; Hodowanec, Aimee C; Colberg-Poley, Anamaris M; Pikis, Andreas; Singer, Mary E; O'Rear, Julian J; Donaldson, Eric F

Komatsu, Takashi E; Hodowanec, Aimee C; Colberg-Poley, Anamaris M; Pikis, Andreas; Singer, Mary E; O'Rear, Julian J; Donaldson, Eric F.

Afiliación

Komatsu TE; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA. Electronic address: takashi.komatsu@fda.hhs.gov.
Hodowanec AC; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA. Electronic address: aimee.hodowanec@fda.hhs.gov.
Colberg-Poley AM; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA.
Pikis A; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA.
Singer ME; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA.
O'Rear JJ; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA.
Donaldson EF; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, Food and Drug Administration, USA. Electronic address: eric.donaldson@fda.hhs.gov.

Antiviral Res ; 169: 104549, 2019 09.

Article en En | MEDLINE | ID: mdl-31279814

Asunto(s)

Citomegalovirus/genética; Farmacorresistencia Viral/genética; Genómica; Proteínas Virales/genética; Proteínas Estructurales Virales/genética; Acetatos/farmacología; Sustitución de Aminoácidos; Antivirales/farmacología; Citomegalovirus/efectos de los fármacos; Endodesoxirribonucleasas/efectos de los fármacos; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Quinazolinas/farmacología; Trasplante de Células Madre

Palabras clave

Drug resistance; HCMV; Letermovir; Next generation sequencing; Stem cell transplantation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Virales / Proteínas Estructurales Virales / Genómica / Citomegalovirus / Farmacorresistencia Viral Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Antiviral Res Año: 2019 Tipo del documento: Article

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