The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice.

Impellizzeri, Daniela; Peritore, Alessio Filippo; Cordaro, Marika; Gugliandolo, Enrico; Siracusa, Rosalba; Crupi, Rosalia; D'Amico, Ramona; Fusco, Roberta; Evangelista, Maurizio; Cuzzocrea, Salvatore; Di Paola, Rosanna

Impellizzeri, Daniela; Peritore, Alessio Filippo; Cordaro, Marika; Gugliandolo, Enrico; Siracusa, Rosalba; Crupi, Rosalia; D'Amico, Ramona; Fusco, Roberta; Evangelista, Maurizio; Cuzzocrea, Salvatore; Di Paola, Rosanna.

Afiliación

Impellizzeri D; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Peritore AF; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Cordaro M; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Gugliandolo E; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Siracusa R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Crupi R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
D'Amico R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Fusco R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Evangelista M; Institute of Anaesthesiology and Reanimation, Catholic University of the Sacred Heart, Rome, Italy.
Cuzzocrea S; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, Messina, Italy.
Di Paola R; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

FASEB J ; 33(10): 11364-11380, 2019 10.

Article en En | MEDLINE | ID: mdl-31344333

Asunto(s)

Neuropatías Diabéticas/tratamiento farmacológico; Etanolaminas/farmacología; Fármacos Neuroprotectores/farmacología; Ácidos Palmíticos/farmacología; Amidas; Analgésicos/farmacología; Animales; Antiinflamatorios/farmacología; Apoptosis/efectos de los fármacos; Citocinas/metabolismo; Neuropatías Diabéticas/metabolismo; Modelos Animales de Enfermedad; Hiperalgesia/tratamiento farmacológico; Hiperalgesia/metabolismo; Inflamación/tratamiento farmacológico; Inflamación/metabolismo; Masculino; Ratones; FN-kappa B/metabolismo; Neovascularización Patológica/tratamiento farmacológico; Neovascularización Patológica/metabolismo; Estrés Nitrosativo/efectos de los fármacos; Estrés Oxidativo/efectos de los fármacos; Dolor/tratamiento farmacológico; Dolor/metabolismo; Nervio Ciático/efectos de los fármacos; Nervio Ciático/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

DPN; PPAR-α; neuroinflammation; oxidative stress; pain

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos Palmíticos / Fármacos Neuroprotectores / Neuropatías Diabéticas / Etanolaminas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia

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