Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B.

Ottanà, Rosaria; Paoli, Paolo; Lori, Giulia; Adornato, Ilenia; Previti, Santo; Naß, Alexandra; Wolber, Gerhard; Maccari, Rosanna

Ottanà, Rosaria; Paoli, Paolo; Lori, Giulia; Adornato, Ilenia; Previti, Santo; Naß, Alexandra; Wolber, Gerhard; Maccari, Rosanna.

Afiliación

Ottanà R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Polo Universitario Annunziata, Viale SS. Annunziata, 98168 Messina, Italy. Electronic address: rottana@unime.it.
Paoli P; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
Lori G; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
Adornato I; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Polo Universitario Annunziata, Viale SS. Annunziata, 98168 Messina, Italy.
Previti S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Polo Universitario Annunziata, Viale SS. Annunziata, 98168 Messina, Italy.
Naß A; Institute of Pharmacy, Computer-Aided Molecular Design, Freie Universitaet Berlin, Koenigin-Luisestr. 2+4, 14195 Berlin, Germany.
Wolber G; Institute of Pharmacy, Computer-Aided Molecular Design, Freie Universitaet Berlin, Koenigin-Luisestr. 2+4, 14195 Berlin, Germany.
Maccari R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Polo Universitario Annunziata, Viale SS. Annunziata, 98168 Messina, Italy.

Bioorg Chem ; 92: 103211, 2019 11.

Article en En | MEDLINE | ID: mdl-31491569

Asunto(s)

Diseño de Fármacos; Inhibidores Enzimáticos/farmacología; Hipoglucemiantes/farmacología; Imidazolidinas/farmacología; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Células Hep G2; Humanos; Hipoglucemiantes/síntesis química; Hipoglucemiantes/química; Imidazolidinas/síntesis química; Imidazolidinas/química; Estructura Molecular; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Relación Estructura-Actividad; Células Tumorales Cultivadas

Palabras clave

3-aryl-5-arylidene-2-thioxo-4-imidazolidinones; Cellular assays; Insulin-sensitizing agents; Non-competitive inhibitors; Protein tyrosine phosphatase 1B

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Imidazolidinas / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Hipoglucemiantes Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article

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