RecQL4 tethering on the pre-replicative complex induces unscheduled origin activation and replication stress in human cells.

Shin, Gwangsu; Jeong, Dongsoo; Kim, Hyunsup; Im, Jun-Sub; Lee, Joon-Kyu

Shin, Gwangsu; Jeong, Dongsoo; Kim, Hyunsup; Im, Jun-Sub; Lee, Joon-Kyu.

Afiliación

Shin G; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Jeong D; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Kim H; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Im JS; Department of Biology Education, Seoul National University, Seoul, 08826, Republic of Korea.
Lee JK; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, 08826, Republic of Korea joonlee@snu.ac.kr.

J Biol Chem ; 294(44): 16255-16265, 2019 11 01.

Article en En | MEDLINE | ID: mdl-31519754

Asunto(s)

Replicación del ADN; RecQ Helicasas/metabolismo; Origen de Réplica; Proteínas de Ciclo Celular/metabolismo; Núcleo Celular/metabolismo; Quinasas Ciclina-Dependientes/metabolismo; Proteínas de Unión al ADN/metabolismo; Células HeLa; Humanos; Complejo de Reconocimiento del Origen/metabolismo; Factores de Iniciación de Péptidos/metabolismo; Fosforilación; Proteínas Serina-Treonina Quinasas/metabolismo; RecQ Helicasas/genética; Fase S; Activación Transcripcional

Palabras clave

DNA replication; RecQL4; cell cycle; cell division cycle 7-related protein kinase (Cdc7); checkpoint control; chromatin immunoprecipitation (ChiP); cyclin-dependent kinase (CDK); origin activation; pre-replicative complex; replication initiation; replication stress; replication timing; transcription-replication conflicts

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Origen de Réplica / Replicación del ADN / RecQ Helicasas Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google