Crystal structure of <i>cis</i>-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.

Chen, Fangfang; Lukat, Peer; Iqbal, Azeem Ahmed; Saile, Kyrill; Kaever, Volkhard; van den Heuvel, Joop; Blankenfeldt, Wulf; Büssow, Konrad; Pessler, Frank

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.

Chen, Fangfang; Lukat, Peer; Iqbal, Azeem Ahmed; Saile, Kyrill; Kaever, Volkhard; van den Heuvel, Joop; Blankenfeldt, Wulf; Büssow, Konrad; Pessler, Frank.

Afiliación

Chen F; Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Lukat P; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.
Iqbal AA; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Saile K; Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Kaever V; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.
van den Heuvel J; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Blankenfeldt W; Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Büssow K; Research Core Unit Metabolomics, Hannover Medical School, 30625 Hannover, Germany.
Pessler F; Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

Proc Natl Acad Sci U S A ; 116(41): 20644-20654, 2019 10 08.

Article en En | MEDLINE | ID: mdl-31548418

Asunto(s)

Carboxiliasas/química; Carboxiliasas/genética; Mutación; Succinatos/metabolismo; Células A549; Secuencia de Aminoácidos; Animales; Carboxiliasas/metabolismo; Catálisis; Dominio Catalítico; Cristalografía por Rayos X; Evolución Molecular; Humanos; Ratones; Modelos Moleculares; Mutagénesis Sitio-Dirigida; Conformación Proteica; Homología de Secuencia

Palabras clave

cis-aconitate; decarboxylase; enzymology; itaconic acid; macrophage

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Succinatos / Carboxiliasas / Mutación Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article País de afiliación: Alemania

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google