Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection.
J Perinatol
; 40(1): 89-96, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31575999
ABSTRACT
OBJECTIVE:
To determine the frequency of abnormal findings on evaluation of neonates with congenital CMV infection who have a normal physical examination STUDYDESIGN:
Retrospective, 2-center study (1996-2017) that reviewed results of complete blood cell count and platelets, serum alanine aminotransferase (ALT) and bilirubin concentrations, eye examination, cranial ultrasonography or other neuroimaging, and brainstem evoked responses performed on neonates with congenital CMV infection and a normal physical examinationRESULTS:
Of 34 infants with congenital CMV infection and a normal physical examination, 56% (19/34) had ≥1 abnormality 39%, elevated ALT concentration; 45%, abnormal neuroimaging (five, lenticulostriate vasculopathy; six, intraventricular hemorrhage; four, calcifications); 12%, anemia; 16%, thrombocytopenia; and 3%, chorioretinitis. Seven (21%) infants had sensorineural hearing loss, and 18 infants received antiviral therapy.CONCLUSION:
Some infants with congenital CMV infection and a normal physical examination had abnormalities on laboratory or neuroimaging evaluation, which in some cases prompted antiviral treatment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Examen Físico
/
Trombocitopenia
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Encéfalo
/
Infecciones por Citomegalovirus
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Alanina Transaminasa
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Male
/
Newborn
Idioma:
En
Revista:
J Perinatol
Asunto de la revista:
PERINATOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos