Deregulation of UCA1 expression may be involved in the development of chemoresistance to cisplatin in the treatment of non-small-cell lung cancer via regulating the signaling pathway of microRNA-495/NRF2.

Li, Chaoyi; Fan, Kai; Qu, Yue; Zhai, Wei; Huang, Ai; Sun, Xiangfu; Xing, Shijie

Li, Chaoyi; Fan, Kai; Qu, Yue; Zhai, Wei; Huang, Ai; Sun, Xiangfu; Xing, Shijie.

Afiliación

Li C; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Fan K; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Qu Y; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhai W; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huang A; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Sun X; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xing S; Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

J Cell Physiol ; 235(4): 3721-3730, 2020 04.

Article en En | MEDLINE | ID: mdl-31583720

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; MicroARNs/genética; Factor 2 Relacionado con NF-E2/genética; ARN Largo no Codificante/genética; Anciano; Cisplatino/administración & dosificación; Cisplatino/efectos adversos; Resistencia a Antineoplásicos/genética; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Masculino; Persona de Mediana Edad; Supervivencia sin Progresión; Transducción de Señal/efectos de los fármacos

Palabras clave

NRF2; UCA1; chemoresistance; miR-495; non-small-cell lung cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / MicroARNs / Factor 2 Relacionado con NF-E2 / ARN Largo no Codificante Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cell Physiol Año: 2020 Tipo del documento: Article País de afiliación: China

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