Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt<sup>Q140/Q140</sup> mouse model of Huntington's disease.

McAdam, Robyn L; Morton, Andrew; Gordon, Sarah L; Alterman, Julia F; Khvorova, Anastasia; Cousin, Michael A; Smillie, Karen J

Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt^Q140/Q140 mouse model of Huntington's disease.

McAdam, Robyn L; Morton, Andrew; Gordon, Sarah L; Alterman, Julia F; Khvorova, Anastasia; Cousin, Michael A; Smillie, Karen J.

Afiliación

McAdam RL; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK.
Morton A; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK.
Gordon SL; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK.
Alterman JF; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Cousin MA; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK. Electronic address: M.Cousin@ed.ac.uk.
Smillie KJ; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK. Electronic address: K.Smillie@ed.ac.uk.

Neurobiol Dis ; 134: 104637, 2020 02.

Article en En | MEDLINE | ID: mdl-31614197

Asunto(s)

Cuerpo Estriado/metabolismo; Endocitosis/fisiología; Proteína Huntingtina/metabolismo; Enfermedad de Huntington/metabolismo; Neuronas/metabolismo; Vesículas Sinápticas/metabolismo; Animales; Modelos Animales de Enfermedad; Técnicas de Sustitución del Gen; Humanos; Proteína Huntingtina/genética; Enfermedad de Huntington/genética; Ratones; Ratones Endogámicos C57BL

Palabras clave

Clathrin; Endocytosis; Endosome; Huntington's disease; Neurodegeneration; Neuron; Synapse; Vesicle

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vesículas Sinápticas / Enfermedad de Huntington / Cuerpo Estriado / Endocitosis / Proteína Huntingtina / Neuronas Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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