Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous <i>Leishmania</i>.

Rodrigues, Vasco; André, Sónia; Maksouri, Hasnaa; Mouttaki, Tarik; Chiheb, Soumiya; Riyad, Myriam; Akarid, Khadija; Estaquier, Jérôme

Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous Leishmania.

Rodrigues, Vasco; André, Sónia; Maksouri, Hasnaa; Mouttaki, Tarik; Chiheb, Soumiya; Riyad, Myriam; Akarid, Khadija; Estaquier, Jérôme.

Afiliación

Rodrigues V; CNRS-ERL3649, Université Paris Descartes, Paris, France.
André S; CNRS-ERL3649, Université Paris Descartes, Paris, France.
Maksouri H; Research Team on Immunopathology of Infectious and Systemic Diseases, Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Mouttaki T; Research Team on Immunopathology of Infectious and Systemic Diseases, Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Chiheb S; Research Team on Immunopathology of Infectious and Systemic Diseases, Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Riyad M; Department of Dermatology, University Hospital Ibn Rochd of Casablanca, Casablanca, Morocco.
Akarid K; Research Team on Immunopathology of Infectious and Systemic Diseases, Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.
Estaquier J; Laboratory of Parasitology, Faculty of Medicine and Pharmacy, University of Hassan II Casablanca (UH2C), Casablanca, Morocco.

Front Cell Infect Microbiol ; 9: 338, 2019.

Article en En | MEDLINE | ID: mdl-31637219

Asunto(s)

Perfilación de la Expresión Génica; Leishmaniasis Cutánea/genética; Transcriptoma; Triptófano Oxigenasa/genética; Animales; Arginina/metabolismo; Biopsia; Línea Celular; Biología Computacional/métodos; Citocinas/genética; Citocinas/metabolismo; Epidermis/metabolismo; Epidermis/parasitología; Epidermis/patología; Ácidos Grasos/metabolismo; Humanos; Mediadores de Inflamación/metabolismo; Leishmania; Leishmaniasis Cutánea/metabolismo; Leishmaniasis Cutánea/parasitología; Leishmaniasis Cutánea/patología; Macrófagos/inmunología; Macrófagos/metabolismo; Macrófagos/parasitología; Ratones; Triptófano Oxigenasa/metabolismo

Palabras clave

3-dioxygenase; Leishmania major; Leishmania tropica; cutaneous leishmanaisis; parasite load; tryptophan-2

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triptófano Oxigenasa / Leishmaniasis Cutánea / Perfilación de la Expresión Génica / Transcriptoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Francia

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