Pseudouridinylation of mRNA coding sequences alters translation.

Eyler, Daniel E; Franco, Monika K; Batool, Zahra; Wu, Monica Z; Dubuke, Michelle L; Dobosz-Bartoszek, Malgorzata; Jones, Joshua D; Polikanov, Yury S; Roy, Bijoyita; Koutmou, Kristin S

Eyler, Daniel E; Franco, Monika K; Batool, Zahra; Wu, Monica Z; Dubuke, Michelle L; Dobosz-Bartoszek, Malgorzata; Jones, Joshua D; Polikanov, Yury S; Roy, Bijoyita; Koutmou, Kristin S.

Afiliación

Eyler DE; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.
Franco MK; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.
Batool Z; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.
Wu MZ; RNA and Genome Editing, New England Biolabs Inc., Ipswich, MA 01938.
Dubuke ML; Proteomics and Mass Spectrometry Facility, University of Massachusetts, Worcester, MA 01545.
Dobosz-Bartoszek M; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA 01605.
Jones JD; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.
Polikanov YS; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.
Roy B; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607; kkoutmou@umich.edu yuryp@uic.edu broy@neb.com.
Koutmou KS; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612.

Proc Natl Acad Sci U S A ; 116(46): 23068-23074, 2019 11 12.

Article en En | MEDLINE | ID: mdl-31672910

Asunto(s)

Biosíntesis de Proteínas; Seudouridina/metabolismo; ARN Bacteriano/genética; ARN Mensajero/genética; Thermus thermophilus/genética; Codón/genética; Codón/metabolismo; Sistemas de Lectura Abierta; Extensión de la Cadena Peptídica de Translación; Seudouridina/genética; Procesamiento Postranscripcional del ARN; ARN Bacteriano/metabolismo; ARN Mensajero/metabolismo; ARN de Transferencia/genética; ARN de Transferencia/metabolismo; Ribosomas/genética; Ribosomas/metabolismo; Thermus thermophilus/metabolismo; Uridina/metabolismo

Palabras clave

mRNA modification; pseudouridine; ribosome; translation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Seudouridina / Biosíntesis de Proteínas / ARN Bacteriano / ARN Mensajero / Thermus thermophilus Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

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