Compensatory Hippocampal Recruitment Supports Preserved Episodic Memory in Autism Spectrum Disorder.
Biol Psychiatry Cogn Neurosci Neuroimaging
; 5(1): 97-109, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31676207
ABSTRACT
BACKGROUND:
The degree to which individuals with autism spectrum disorder (ASD) evidence impairments in episodic memory relative to their typically developing (TD) counterparts remains unclear. According to a prominent view, ASD is associated with deficits in encoding associations between items and recollecting precise context details. Here, we evaluated behavioral and neural evidence for this impaired relational binding hypothesis using a task involving relational encoding and recollection during functional magnetic resonance imaging.METHODS:
Adolescents and young adults (nASD = 47, nTD = 60) performed the Relational and Item-Specific Encoding task during functional magnetic resonance imaging, including item and associative recognition testing. We modeled functional recruitment within the medial temporal lobes (MTLs), and connectivity between MTL and the posterior medial (PM) network thought to underlie relational memory. The impaired relational binding model would predict a behavioral deficit driven by aberrant recruitment and connectivity of MTL and the PM network.RESULTS:
The ASD and TD groups showed indistinguishable item and associative recognition performance. During relational encoding, the ASD group demonstrated increased hippocampal recruitment, and decreased connectivity between MTL and PM regions relative to the TD group. Within ASD, hippocampal recruitment and MTL-PM connectivity were inversely correlated.CONCLUSIONS:
The lack of a behavioral deficit in ASD does not support the impaired relational binding hypothesis. Instead, the current data suggest that increased recruitment of the hippocampus compensates for decreased MTL-PM connectivity to support preserved episodic memory in ASD. These findings suggest a compensatory neurodevelopmental mechanism that may support preserved cognitive domains in ASD local hyperrecruitment may offset connectivity aberrations in individuals with ASD relative to TD subjects.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Memoria Episódica
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Trastorno del Espectro Autista
/
Hipocampo
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
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Child
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Psychiatry Cogn Neurosci Neuroimaging
Año:
2020
Tipo del documento:
Article