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Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile.
Werner, Stefan; Mesch, Stefanie; Hillig, Roman C; Ter Laak, Antonius; Klint, Julie; Neagoe, Ioana; Laux-Biehlmann, Alexis; Dahllöf, Henrik; Bräuer, Nico; Puetter, Vera; Nubbemeyer, Reinhard; Schulz, Simone; Bairlein, Michaela; Zollner, Thomas M; Steinmeyer, Andreas.
Afiliación
  • Werner S; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Mesch S; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Hillig RC; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Ter Laak A; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Klint J; Evotec SE , 22419 Hamburg , Germany.
  • Neagoe I; Evotec SE , 22419 Hamburg , Germany.
  • Laux-Biehlmann A; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Dahllöf H; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Bräuer N; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Puetter V; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Nubbemeyer R; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Schulz S; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Bairlein M; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Zollner TM; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Steinmeyer A; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
J Med Chem ; 62(24): 11194-11217, 2019 12 26.
Article en En | MEDLINE | ID: mdl-31746599
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dolor / Citocromo P-450 CYP3A / Descubrimiento de Drogas / Receptores Purinérgicos P2X4 / Antagonistas del Receptor Purinérgico P2X / Inductores del Citocromo P-450 CYP3A / Inflamación / Acetamidas Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dolor / Citocromo P-450 CYP3A / Descubrimiento de Drogas / Receptores Purinérgicos P2X4 / Antagonistas del Receptor Purinérgico P2X / Inductores del Citocromo P-450 CYP3A / Inflamación / Acetamidas Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Alemania