Enantioanalysis of tryptophan in whole blood samples using stochastic sensors-A screening test for gastric cancer.
Chirality
; 32(2): 215-222, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31747471
ABSTRACT
Tryptophan is a key amino acid related to metabolomics in gastric cancer. To date, methods were developed only for the assay of l-tryptophan, the role of d-tryptophan being not yet established. Therefore, four stochastic sensors based on different graphene materials modified with ß-cyclodextrins, 2,2-diphenyl-1-picrylhydrazyl, and protoporphyrin IX were designed and used for enantioanalysis of tryptophan in whole blood samples. High sensitivities, and reliabilities were recorded when the stochastic sensors were used for the enantioanalysis of tryptophan in whole blood samples. The paper opened a new chapter in early detection of gastric cancer, based on establishing the role of d-tryptophan in metabolomics, and in early diagnosis of gastric cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Triptófano
/
Análisis Químico de la Sangre
/
Detección Precoz del Cáncer
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Chirality
Asunto de la revista:
BIOLOGIA MOLECULAR
/
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Rumanía