Curcumin analog CUR5-8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity.
Metabolism
; 103: 154015, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31758951
ABSTRACT
OBJECTIVE:
Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat storage in the liver and it is strongly linked with metabolic syndrome including obesity, insulin resistance, dyslipidemia and hypertension. Curcumin5-8 (CUR5-8) is a synthetic derivative of naturally active curcumin (CUR) that has anti-oxidative and anti-inflammatory properties. In the present study, we investigated the effects of CUR5-8, a novel CUR analog, on hepatic steatosis in mice with high-fat diet (HFD)-induced obesity.METHODS:
Based on their diets for 13â¯weeks, the mice were categorized into the following six groups regular diet (RD, nâ¯=â¯10), RD with CUR (RDâ¯+â¯CUR, 100â¯mg/kg/day, nâ¯=â¯10), RD with CUR5-8 (RDâ¯+â¯CUR5-8, 100â¯mg/kg/day, nâ¯=â¯10), high-fat diet-induced obese mice (HFD, nâ¯=â¯10), HFD with CUR (HFDâ¯+â¯CUR, 100â¯mg/kg/day, nâ¯=â¯10), and HFD with CUR5-8 (HFDâ¯+â¯CUR5-8, 100â¯mg/kg/day, nâ¯=â¯10) for 13â¯weeks. Hematoxylin and eosin (H&E) staining of the sections revealed hepatic steatosis.RESULTS:
CUR5-8 administration prevented increase in body and liver weights in mice with HFD-induced obesity. Compared to the HFD group, insulin resistance was significantly improved in the HFDâ¯+â¯CUR5-8 group. Serum alanine aminotransferase level, which is an indicator of liver damage, was also decreased after CUR5-8 administration. H&E staining revealed that CUR5-8 treatment decreased hepatic steatosis in mice with HFD-induced obesity. Interestingly, CUR5-8, and not CUR, decreased the elevated liver triglyceride level induced by the HFD.CONCLUSIONS:
These findings suggest that CUR5-8 ameliorates insulin resistance and hepatic steatosis in mice with HFD-induced obesity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Curcumina
/
Dieta Alta en Grasa
/
Enfermedad del Hígado Graso no Alcohólico
/
Obesidad
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Metabolism
Año:
2020
Tipo del documento:
Article