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Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides.
Phyo, Ma Yadanar; Ding, Chi Ying Gary; Goh, Hui Chin; Goh, Jun Xian; Ong, Ji Fa Marshall; Chan, Siew Herng; Yung, Pui Yi Maria; Candra, Hartono; Tan, Lik Tong.
Afiliación
  • Phyo MY; Natural Sciences and Science Education, National Institute of Education , Nanyang Technological University , 1 Nanyang Walk , Singapore 637616 , Singapore.
  • Ding CYG; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551 , Singapore.
  • Goh HC; Natural Sciences and Science Education, National Institute of Education , Nanyang Technological University , 1 Nanyang Walk , Singapore 637616 , Singapore.
  • Goh JX; p53 Laboratory , Agency for Science, Technology and Research (A*STAR) , #06-06, Immunos, 8A Biomedical Grove , Singapore 138648 , Singapore.
  • Ong JFM; Natural Sciences and Science Education, National Institute of Education , Nanyang Technological University , 1 Nanyang Walk , Singapore 637616 , Singapore.
  • Chan SH; Natural Sciences and Science Education, National Institute of Education , Nanyang Technological University , 1 Nanyang Walk , Singapore 637616 , Singapore.
  • Yung PYM; Singapore Centre for Environmental Life Sciences Engineering , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551 , Singapore.
  • Candra H; Singapore Centre for Environmental Life Sciences Engineering , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551 , Singapore.
  • Tan LT; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551 , Singapore.
J Nat Prod ; 82(12): 3482-3488, 2019 12 27.
Article en En | MEDLINE | ID: mdl-31763840
ABSTRACT
A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Agua de Mar / Cianobacterias / Antineoplásicos Límite: Humans Idioma: En Revista: J Nat Prod Año: 2019 Tipo del documento: Article País de afiliación: Singapur
Texto completo
Imprimir
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Agua de Mar / Cianobacterias / Antineoplásicos Límite: Humans Idioma: En Revista: J Nat Prod Año: 2019 Tipo del documento: Article País de afiliación: Singapur