Pharmacology of mitochondrial permeability transition pore inhibitors.
Drug Dev Res
; 80(8): 1013-1030, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31823411
ABSTRACT
It is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability transition pores (mPTPs), which changes the permeability of the mitochondria. mPTP opening results in the death of cardiomyocytes through activation of apoptosis and necroptosis. Experimental studies have shown that pharmacological inhibition of mPTP opening promotes the reduction in the infarct size and the suppression of apoptosis. Indeed, studies have shown the efficacy of mPTP inhibitors in animal models of myocardial reperfusion and isolated human myocardial trabeculae. However, clinical trials of cyclosporin A and TRO40303 have not provided a clear answer to the question of the effectiveness of mPTP inhibitors in patients with acute myocardial infarction. This article presents an analysis of possible approaches for the pharmacological regulation of mPTP during reperfusion injury of the heart.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oximas
/
Secoesteroides
/
Daño por Reperfusión Miocárdica
/
Ciclosporina
/
Proteínas de Transporte de Membrana Mitocondrial
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Dev Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia