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The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine.
Dickson, Dane; Johnson, Jennifer; Bergan, Raymond; Owens, Rebecca; Subbiah, Vivek; Kurzrock, Razelle.
Afiliación
  • Dickson D; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA; Taproot Health, Salt Lake City, UT, USA. Electronic address: dane.dickson@taprootco.com.
  • Johnson J; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
  • Bergan R; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
  • Owens R; Taproot Health, Salt Lake City, UT, USA.
  • Subbiah V; University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kurzrock R; Moores Cancer Center, University of California at San Diego, San Diego, CA, USA.
Cell ; 180(1): 9-14, 2020 01 09.
Article en En | MEDLINE | ID: mdl-31951522
ABSTRACT
This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proyectos de Investigación / Estudios Observacionales como Asunto / Medicina de Precisión Tipo de estudio: Guideline / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proyectos de Investigación / Estudios Observacionales como Asunto / Medicina de Precisión Tipo de estudio: Guideline / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article