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Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib.
Christodoulou, Michael S; Mori, Mattia; Pantano, Rebecca; Alfonsi, Romina; Infante, Paola; Botta, Maurizio; Damia, Giovanna; Ricci, Francesca; Sotiropoulou, Panagiota A; Liekens, Sandra; Botta, Bruno; Passarella, Daniele.
Afiliación
  • Christodoulou MS; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano (Italy), Fax: (+39) 02-50314078.
  • Mori M; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Roma (Italy).
  • Pantano R; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano (Italy), Fax: (+39) 02-50314078.
  • Alfonsi R; Department of Molecular Medicine, University La Sapienza, 00161 Rome (Italy).
  • Infante P; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Roma (Italy).
  • Botta M; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena (Italy).
  • Damia G; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg. Suite 333, 1900 N 12th Street, Philadelphia, PA 19122 (USA).
  • Ricci F; Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano (Italy).
  • Sotiropoulou PA; Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano (Italy).
  • Liekens S; IRIBHM, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels (Belgium).
  • Botta B; Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, blok x-bus 1030, 3000 Leuven (Belgium).
  • Passarella D; Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma (Italy).
Chempluschem ; 80(6): 938-943, 2015 Jun.
Article en En | MEDLINE | ID: mdl-31973263
ABSTRACT
The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is inhibited by the lead compound Vismodegib. Based on molecular modeling simulations, seven triazole derivatives of Vismodegib are synthesized and their biological effect on different endothelial, cancer, and cancer stem cell lines is reported.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chempluschem Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chempluschem Año: 2015 Tipo del documento: Article