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Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study.
Coppini, Raffaele; Ferrantini, Cecilia; Pioner, Josè Manuel; Santini, Lorenzo; Wang, Zhinuo J; Palandri, Chiara; Scardigli, Marina; Vitale, Giulia; Sacconi, Leonardo; Stefàno, Pierluigi; Flink, Laura; Riedy, Katherine; Pavone, Francesco Saverio; Cerbai, Elisabetta; Poggesi, Corrado; Mugelli, Alessandro; Bueno-Orovio, Alfonso; Olivotto, Iacopo; Sherrid, Mark V.
Afiliación
  • Coppini R; Department NeuroFarBa, University of Florence, Florence, Italy.
  • Ferrantini C; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Pioner JM; Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
  • Santini L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Wang ZJ; Department NeuroFarBa, University of Florence, Florence, Italy.
  • Palandri C; Department of Computer Sciences, University of Oxford, Oxford, United Kingdom.
  • Scardigli M; Department NeuroFarBa, University of Florence, Florence, Italy.
  • Vitale G; European Laboratory for Nonlinear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, Italy and National Institute of Optics, National Research Council, Florence, Italy.
  • Sacconi L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Stefàno P; European Laboratory for Nonlinear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, Italy and National Institute of Optics, National Research Council, Florence, Italy.
  • Flink L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Riedy K; Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
  • Pavone FS; Division of Cardiology, San Francisco Veterans Affairs Medical Center and University of California-San Francisco, San Francisco, California.
  • Cerbai E; Hypertrophic Cardiomyopathy Program, New York University Langone Health, New York, New York.
  • Poggesi C; European Laboratory for Nonlinear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, Italy and National Institute of Optics, National Research Council, Florence, Italy.
  • Mugelli A; Department NeuroFarBa, University of Florence, Florence, Italy.
  • Bueno-Orovio A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Olivotto I; Department NeuroFarBa, University of Florence, Florence, Italy.
  • Sherrid MV; Department of Computer Sciences, University of Oxford, Oxford, United Kingdom.
JACC Basic Transl Sci ; 4(7): 795-813, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31998849
Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion channels, leading to lower Ca transients and force, and shortens action potentials, thus reducing cellular arrhythmias. The electrophysiological profile of disopyramide explains the efficient reduction of outflow gradients but also the limited prolongation of the QT interval and the absence of arrhythmic side effects observed in 39 disopyramide-treated patients. In conclusion, our results support the idea that disopyramide is safe for outpatient use in obstructive patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2019 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2019 Tipo del documento: Article País de afiliación: Italia